目的

观察安慰疗法加中草药对乳痛症伴抑郁、焦虑情绪患者的临床疗效。

方法

选取本院2011 年3 月至11 月就诊的视觉模拟评分(VAS)≥6,抑郁自评量表评分(SDS)≥50,或/和焦虑自评量表评分(SAS)≥53 的乳痛症患者随机分为中草药组(n=32)和精神安慰加中草药联合治疗组(n=30),并用VAS 及Cardiff 乳房疼痛量表分别在治疗前、治疗后1 个月及2 个月评估疗效。 计量资料用t检验,组间比较用重复测量的方差分析,计数资料用卡方检验。

结果

中草药组治疗前VAS 为6.12±0.49, 治疗后2 个月为5.19±1.00, 差异有统计学意义(t=4.676,P=0.000);联合治疗组治疗前VAS 为6.27±0.69,治疗后2 个月为5.07±1.01,差异有统计学意义(t=5.835,P=0.000);但组间比较差异无统计学意义(P=0.585)。 在Cardiff 评分方面,中草药组治疗前为7.64±2.9,治疗后2 个月为5.55±2.32,差异有统计学意义(t=4.924,P=0.000);联合治疗组治疗前为7.05±2.4,治疗后2 个月为4.02±1.39,差异有统计学意义(t=8.096,P=0.000);组间比较差异有统计学意义(F=6.922, P=0.011)。

结论

对于伴有焦虑、抑郁情绪的乳痛症患者,中草药治疗有一定效果,在此基础上加上精神安慰可以进一步改善疗效。

Objective

To investigate the therapeutic effects of reassurance combined with Chinese herbal drugs on mastodynia patients with depression and anxiety.

Methods

The mastodynia patients admitted in our hospital from March to November 2011, with visual analogue scale(VAS)≥6, self-rating depressive scale (SDS)≥50 and self-rating anxiety scale (SAS)≥53, were enrolled in the study. They were randomized to receive either Chinese herbal therapy (CH group, n=32) or reassurance coupled with CH (RCH group, n=30) for two months. The intensity of mastodynia was assessed before treatment, after treatment 1 month and 2 months using visual analogue scale (VAS) and the Cardiff breast pain chart. Measurement data was analyzed using t-test, group comparison using repeated measurement ANOVA analysis, and count data using the chisquare test.

Results

VAS in CH group was 6.12±0.49 before treatment, 5.19±1.00 at 2 months after treatment and the difference was statistically significant(t=4.676,P=0.000). VAS in RCH group was 6.27±0.69 before treatment,5.07±1.01 at 2 months after treatment and the difference was statistically significant(F=6.922, P=0.011). Group comparison on VAS showed no statistical difference (P=0.585). Cardiff score in CH group was 7.64±2.9 before treatment, 5.55±2.32 at 2 months after treatment and the difference was statistically significant (t=4.924,P=0.000). Cardiff score in RCH group was 7.05±2.4 before treatment,4.02±1.39 at 2 months after treatment and the difference was statistically significant (t=8.096,P=0.000).Group comparison on Cardiff score showed statistical difference(F=6.922, P=0.011).

Conclusion

For the mastodynia patients with anxiety and depression, Chinese herbal therapy is effective, if combined with rassurance, the clinical outcome is more satisfactory.